In the old days, when websites were steam powered and exploded regularly, the web was simple, but slow. As it evolved it became more powerful, but harder on servers and clients alike.
Today, we have the Single Page Application. Most web apps are now in the browsers themselves, and the web is becoming fluid, comfortable, and accessible from any device.
Slides can be viewed here: http://html5devconf.com/archives/october2012/slides/Michael-S-Mikowski-Tuesday-2012-10-16-js4spa.pdf
** More videos on HTML5 development at http://marakana.com/s/